{"id":25071,"date":"2023-01-23T11:33:11","date_gmt":"2023-01-23T10:33:11","guid":{"rendered":"https:\/\/schrader-institute.de\/praxiswissen\/hdrs-hybrid-diffuse-reflectance-spectroscopy\/"},"modified":"2023-08-02T08:45:40","modified_gmt":"2023-08-02T07:45:40","slug":"hdrs-hybrid-diffuse-reflectance-spectroscopy","status":"publish","type":"praxiswissen","link":"https:\/\/schrader-institute.de\/en\/knowledge\/hdrs-hybrid-diffuse-reflectance-spectroscopy\/","title":{"rendered":"HDRS &#8211; Hybrid Diffuse Reflectance Spectroscopy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"25071\" class=\"elementor elementor-25071 elementor-25063\" data-elementor-post-type=\"praxiswissen\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0c94900 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0c94900\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-baaff83\" data-id=\"baaff83\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ff18425 elementor-widget elementor-widget-heading\" data-id=\"ff18425\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Non-erythemal in vivo testing of SPF<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4a5e2ac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4a5e2ac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d95b5a0\" data-id=\"d95b5a0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6fe5fea elementor-widget elementor-widget-text-editor\" data-id=\"6fe5fea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In order to define a label SPF of topically applied sunscreens in vivo test methods like ISO 24444, FDA-Guideline, or the Australian Standard are used worldwide. Basis of all these methods is provoking an erythemal skin reaction by UV-irradiation to find the level MEDu and MEDp. In vitro methods replacing the human skin by any kind of non-human material are still not available. Thus, offering the new Hybrid Diffuse Reflectance Spectroscopy (HDRS) technique that is able to stay on an in vivo level for SPF testing but meanwhile neglecting the UV-dose related erythemal skin reaction is a perfect combination to take care of sun protection and any ethical concerns in SPF testing nowadays.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5643ed9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5643ed9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dff07d9\" data-id=\"dff07d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-39bf4fe elementor-widget elementor-widget-text-editor\" data-id=\"39bf4fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>HDRS is a combination of in vivo Diffuse Reflectance Spectroscopy (DRS) measurements on the skin and in vitro transmission measurements of a sunscreen on a roughened Polymethylmethacrylate-plate (PMMA plate). By this technique, the in vivo behavior of the investigated sunscreen on the skin is measured as well as the UVB-absorption, which is still non-visible in the reflectance technique. In order to establish an alternative method for in vivo SPF testing a huge number of sunscreens (80 samples) was measured by HDRS and compared to the worldwide accepted standard ISO 24444. The variety of sunscreens measured, reflect a wide range of different types of formulations as well as a wide range of SPF\u2019s (5-120) to validate this new alternative SPF testing procedure.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b9233d elementor-widget elementor-widget-text-editor\" data-id=\"3b9233d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Applied quantity of product as well as skin color dependencies of signal generation are shown to support any basic correlation of DRS-signal generation and sun protection expectations. Far-reaching statistical data analyses show an excellent link of the new non-erythemal driven HDRS-SPF technique and ISO 24444 results. In the same way HDRS-UVA-PF results can be correlated with UVA-PF values calculated from ISO 24443.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9df2e9 elementor-widget elementor-widget-text-editor\" data-id=\"b9df2e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Due to the elimination of any erythemal relevant UVB- and UVA-doses absolutely no skin reaction occurs. Consequently there is no need to define a MED any more. For the first time an alternative way to SPF is shown without any ethical concerns of SPF testing in vivo and\/or any restriction of SPF testing in vitro. Regardless of the type of formulation or the level of protection an excellent correlation of SPFHDRS and SPF24444 for sunscreen labeling could be found. By this new alternative non erythemal technique not only SPF values can be measured, but also UVA-PF values can be calculated with an excellent correlation to ISO 24443 from the same set of data. For the first time a robust alternative test method of SPF- and UVA-PF values is described, taking into account the interaction of sunscreen formulation and skin.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In order to define a label SPF of topically applied sunscreens in vivo test methods like ISO 24444, FDA-Guideline, or the Australian Standard are used worldwide. Basis of all these methods is provoking &#8230;<\/p>\n","protected":false},"featured_media":25065,"parent":0,"template":"","class_list":["post-25071","praxiswissen","type-praxiswissen","status-publish","has-post-thumbnail","hentry","produktkategorie-sun-protection","leistungen-testing-skin"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HDRS - Hybrid Diffuse Reflectance Spectroscopy - Institute Dr. Schrader<\/title>\n<meta name=\"description\" content=\"Institute Dr. Schrader - HDRS - Hybrid Diffuse Reflectance Spectroscopy - The newest development from Schrader Institute.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/schrader-institute.de\/en\/knowledge\/hdrs-hybrid-diffuse-reflectance-spectroscopy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HDRS - Hybrid Diffuse Reflectance Spectroscopy - Institute Dr. Schrader\" \/>\n<meta property=\"og:description\" content=\"Institute Dr. Schrader - HDRS - Hybrid Diffuse Reflectance Spectroscopy - The newest development from Schrader Institute.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/schrader-institute.de\/en\/knowledge\/hdrs-hybrid-diffuse-reflectance-spectroscopy\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute Dr. Schrader\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-02T07:45:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/schrader-institute.de\/wp-content\/uploads\/2023\/01\/hdrs.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/\",\"url\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/\",\"name\":\"HDRS - Hybrid Diffuse Reflectance Spectroscopy - Institute Dr. Schrader\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/schrader-institute.de\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/hdrs.jpg\",\"datePublished\":\"2023-01-23T10:33:11+00:00\",\"dateModified\":\"2023-08-02T07:45:40+00:00\",\"description\":\"Institute Dr. Schrader - HDRS - Hybrid Diffuse Reflectance Spectroscopy - The newest development from Schrader Institute.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/#primaryimage\",\"url\":\"https:\\\/\\\/schrader-institute.de\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/hdrs.jpg\",\"contentUrl\":\"https:\\\/\\\/schrader-institute.de\\\/wp-content\\\/uploads\\\/2023\\\/01\\\/hdrs.jpg\",\"width\":400,\"height\":300,\"caption\":\"HDRS\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/knowledge\\\/hdrs-hybrid-diffuse-reflectance-spectroscopy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/schrader-institute.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"HDRS &#8211; 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